News

2013.09.27 | Research news

Torben Heick Jensen awarded ERC Advanced Grant

The European Research Council (ERC) has awarded an Advanced Grant to Professor Torben Heick Jensen to support his research into genome expression, stability and technology.

2013.07.14 | Research news

How human gene promoters become directional

An international research team has disclosed how cellular gene transcription and RNA degradation processes collaborate to achieve a directional output from human genes.

2013.07.02 | Research news

Identification of a novel mRNA degradation pathway in humans

Researchers from Denmark and Poland have uncovered a novel molecular pathway, which regulates gene expression in the cytoplasm of human cells. The finding has implications for the human diseases; the Perlman syndrome of overgrowth and Wilms' tumor development.

2013.04.05 | Research news

Torben Heick Jensen speaker at highly esteemed lecture series

Torben Heick Jensen - Professor at the Department of Molecular Biology and Genetics and Director of the Danish National Research Foundation-funded centre for mRNP Biogenesis and Metabolism - has been invited to give a talk in the prestigious ‘Mendel Lecture series’. The event is taking place on 18th April 2013 in Brno, the Czech Republic.

Welcome

The regulation and fidelity of gene expression is of paramount importance for the maintenance and differentiation of all living organisms. While attention historically has been focused on the process of gene activation (transcription), the past two decades have highlighted an equally important contribution to gene regulation at the post-transcriptional level. The Centre for mRNP Biogenesis and Metabolism studies the crosstalk between transcriptional and post-transcriptional processes, which establishes a network of interdependencies that ultimately regulate gene expression. Our focus is on structure/function relationships of mRNP formation and its quality control as well as the occurrence, and putative function, of non-coding RNA transcription.


So far our efforts have led to several important discoveries, including:

  • yeast cryptic unstable transcripts (CUTs) and human promoter upstream transcripts (PROMPTs)

  • the elucidation of regulatory principles for mRNP quality control in the nucleus and the cytoplasm

  • the "reverse" cross-talk between mRNA processing and transcription

  • key structures of RNP factors and complexes


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Revised 2013.12.05

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