The regulation and fidelity of gene expression is of paramount importance for the maintenance and differentiation of all living organisms. Our laboratory studies the production and quality control of RNA in eukaryotic cells (S. cerevisiae, mouse and human) and its contribution to gene expression regulation. A main focus of the laboratory is to understand the molecular principles dictating the sorting of newly transcribed RNA into a productive pathway involving its packaging with protein and cellular transport vs. a destructive pathway leading to RNA turnover. We believe that a thorough understanding of these relationships will also position us to better understand any putative function of the pervasive transcription of eukaryotic genomes.
Laboratory efforts can roughly be divided into four research topics:
From 2005-2015 Torben Heick Jensen was heading the Danish National Research Foundation-funded ‘Centre for mRNP Biogenesis and Metabolism’. These, and other, efforts are now continued via funding from the European Research Council (ERC), the Danish Council for Independent Research, the Novo Nordisk foundation, the Lundbeck Foundation and the Danish Cancer Society. The THJ laboratory is also part of the iSEQ Centre for Integrative Sequencing (www.iseq.au.dk).
2017.03.21 | Research news
Our genomes are promiscuously transcribed into RNA. How cells manage to sort this massive genomic output into functional and non-functional material has remained enigmatic. New research describes protein interactions involved in such RNA fate determination.
2016.12.16 | Research news
RNA synthesis, splicing and degradation are key activities in eukaryotic gene expression regulation. A collaborative effort between researchers from the Max Planck Institute, Martinsried and Aarhus University now reveals the physical basis for linking RNA degradation to the splicing process.
2016.11.07 | Research news
Genomes are promiscuously transcribed into RNA. However, not all of this material is immediately useful, which means it has to be targeted and degraded in order to sustain cellular life. A newly discovered RNA decay pathway functioning inside human nuclei does just that
2016.08.15 | Research news
Intense investigations during the past 10-15 years have revealed that the human genome is transcribed in a manner that is much more complicated than previously appreciated. A collaboration between researchers from Aarhus and Copenhagen now reveals some underlying principles leading to such promiscuous genome activity.
2016.10.28 | Events
Claudia successfully defended her PhD October 26th. Congratulations and Good Luck with your future!
2016.10.28 | Events
Jan successfully defended his PhD October 25th. Congratulations and Good Luck with your future in the Czech Republic!
2016.09.20 | PhD defense, Events
Kinga successfully defended her PhD September 1st. Congratulations!