2015.06.26 | Research news

Surprising new mechanism for gene expression regulation

A new important role for a protein connected to the proper function of neurons has been discovered by a research group from MBG, Aarhus University. The studies shed new light on gene expression regulation and may ultimately lead to an understanding of how neurological defects occur when this protein is mutated.

2015.01.09 | Research news

How to target the RNA decay machinery

In collaboration with two other European groups, researchers from Aarhus University have uncovered molecular details leading to targetting of the major RNA decay machinery, the RNA exosome, to its nuclear RNA substrates. Studies can now be designed to address the role of this early nuclear RNA decay pathway in processes where rapid RNA decay may…

2014.11.20 | Research news

A novel strategy to sort functional from non-functional RNA

The human genome is promiscuously transcribed yielding RNA from >75% of its DNA. It is presently intensely debated how much of this material is functional. Danish researchers have devised a method to help address this problem.

2014.11.18 | Research news

Host genes under the knife

A Danish research team has analysed the use of a particular cellular RNA degradation mechanism, which has revealed how the expression of the most complex class of genes in human cells is controlled. The study contributes to an understanding of the cell’s basic regulatory tools, and the results may eventually lead to a better understanding of the…


The regulation and fidelity of gene expression is of paramount importance for the maintenance and differentiation of all living organisms. While attention historically has been focused on the process of gene activation (transcription), the past two decades have highlighted an equally important contribution to gene regulation at the post-transcriptional level. The Centre for mRNP Biogenesis and Metabolism studies the crosstalk between transcriptional and post-transcriptional processes, which establishes a network of interdependencies that ultimately regulate gene expression. Our focus is on structure/function relationships of mRNP formation and its quality control as well as the occurrence, and putative function, of non-coding RNA transcription.

So far our efforts have led to several important discoveries, including:

  • yeast cryptic unstable transcripts (CUTs) and human promoter upstream transcripts (PROMPTs)

  • the elucidation of regulatory principles for mRNP quality control in the nucleus and the cytoplasm

  • the "reverse" cross-talk between mRNA processing and transcription

  • key structures of RNP factors and complexes

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Revised 2015.08.06

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